Image: DermstoreMedik8 · Dermstore
Medik8 Crystal Retinal 6
Why it made the list
A night serum-cream with a built-in ramp-up schedule, so you ease into retinal instead of guessing. The next step for anyone already comfortable with retinol.
A hydrating overnight serum-cream with 0.06% retinaldehyde (retinal) in a 30 ml tube, plus hyaluronic acid, vitamin C derivatives, squalane and vitamin E. Used in the evening after cleansing: twice a week for two weeks, then every other night for two weeks, then nightly, followed by moisturizer. Medik8 suggests it for people who have used its Crystal Retinal 3 or strong retinol products.
Shop at Dermstore ↗$87.00 as of November 7, 2026. Prices change; check the merchant.
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